Welcome to Episode 6 of our monthly GU Cast Journal Club! Two important papers in upper tract urothelial cancer (the POUT trial of adjuvant chemo post nephro-ureterectomy), and metastatic testicular cancer (the SEMS trial of surgery for early metastatic seminoma). We are delighted to welcome back our GU Cast Journal Club Editors, Dr Carlos Delgado (Melbourne, AUS), and Dr Elena Berg (Munich, GER), along with main GU Cast Hosts, Renu Eapen and Declan Murphy. No prostate cancer today, and go easy on Declan he is struggling with man flu!

It is the eve of the USANZ ASM here in Melbourne (which Renu is Convening!), and some of the 27 International guests are already into town. So we grabbed Anders Bjartell (Lund University/University Hospital Malmo, SWE), for a sit down chat in studio. Anders has been a huge name in prostate cancer research in Europe for the past couple of decades, including as a senior investigator on TITAN. so we decided to pick his brain on three topical areas in prostate cancer.

Giant bladder cancer paper in NEJM this week with the highly anticipated results of the perioperative EV-Pembro trial (EV-303 / KN-905). Already we can say this is a landmark publicaion in bladder cancer that will change practice and even challenge the role of cystectomy (maybe)! 

Following on from last week's episode on "toxicity", we are delighted today to welcome back two great friends of GU Cast from the world of radiation oncology - ASTRO President Dr Neha Vapiwala (University of Pennsylvania), and European Urology Associate Editor, Dr Amar Kishan (University of California, Los Angeles). We go through Amar and Neha's letter to the editor following the recent paper in Eur Urol Oncol from the IRRADIATE registry, and dive into the opportunities we have working in multidisciplinary teams to look after our prostate cancer patients. Most enjoyable!

In case you missed it, or you've already abandoned Twitter (memo to self - must do that ourselves!), we witnessed some pretty toxic stuff over there in the past couple of weeks. Vile personal attacks, calls for resignations, accusations of nefarious behaviour etc etc, mostly triggered by an AI-generated infographic attempting to illustarte a recent paper in European Urology Oncology. We chat with first author Dr Riccardo Bertolo (University of Verona, ITA), about his first-hand experience of twitter toxicity, his take on that terrible infographic, and ,most importantly, we discuss the paper which he and his colleagues published on late GU toxicity following prostate cancer radiation.

Happy New Year and welcome to Episode 5 of our monthly GU Cast Journal Club! Today we focus on two classic papers in non-invasive bladder cancer and metastatic prostate cancer. The Lamm RCT of maintenance BCG is a landmark trial for all sorts of reasons, published in J Urol in 2000. And the CHAARTED paper of chemohormonal therapy is the landmark trial of combination therapy in mHSPC, published in NEJM in 2015.

Episode 4 of our monthly GU Cast Journal Club and today we focus on two important papers in prostate cancer diagnostics and bladder cancer surgery. The PRECISION NEJM paper 2018 is a landmark publication which defined the role of mpMRI in early detection, and changed practice in many countries. The EB-StaR trial should also change practice after its European Urology 2024 publication, but has it??! We are delighted to welcome back our GU Cast Journal Club Editors, Dr Carlos Delgado (Melbourne, AUS), and Dr Elena Berg (Munich, GER), along with main GU Cast Hosts, Renu Eapen and Declan Murphy. A very lively discussion!!

An exclusive behind-the-scenes look at the world-famous ORSI Academy in Belgium! Declan and Renu travelled to this remarkable facility just outside Ghent in Belgium, jammed full of tens of millions of dollars worth of robotic surgery technology from the world's top providers - Intuitive Surgical, Medtronic, Microport and more. Every day, surgeons from all around the world are getting hands-on experience using the latest robotic surgery technology in an array of training environments. Plus ORSI Academy hosts many academic programs, live surgery events, telesurgery demonstrations, and is actually expanding to do even more!

World-renowned sexual health expert, Dr Chris Nelson, Chief of Psychology at Memorial Sloan-Kettering Cancer Centre, joins us in studio to run through the new Movember-supported "Guidelines for Sexual Health Care for Prostate Cancer Patients". A really helpful overview and structure for anyone working in this field, and for patients and their loved ones. Chris shares his 20-plus years of experience working in this field at one of the world's premier prostate cancer centres.

We recently hosted another live webinar for our Gold Partners, Mundipharma, this time asking the question, "Is high-risk BCR actually metastatic prostate cancer??". It's a reasonable question! This podcast was anchored from the GU Cast studio in Melbourne by usual hosts, Renu Eapen and Declan Murphy, joined in person by Andrew Loblaw, radiation oncologist from Toronto, and online by medical oncologist Jeff Goh in Brisbane.